Association ranging from fat reduction calcium and you will magnesium consumption and you may nightmare in almost any sex groups
Results
Table 1 reveals might services of ten,798 players who’d over information throughout the NHANES 1999–2004 research. Of those people, dos,123 (19.7%) got migrainepared so you’re able to non-headache, nightmare was in fact very likely to become more youthful, people, non-Hispanic Black colored, previous consuming, latest smoking, enjoys lower education height, straight down prevalence regarding blood pressure level, high Body mass index, higher carbohydrate intake, all the way down calcium and you will magnesium intake, and lower supplement D complement intake. The common each day intake out of calcium and magnesium try somewhat lower than simply the particular needed fat loss allowances (RDAs), as found inside the Desk 2.
Table 3 shows a significant inverse association between dietary calcium and magnesium intake and migraine after adjusting for the possible confounders. The ORs (95% CI) for the association between dietary calcium intake and migraine were 0.85 (0.73–0.99) and 0.77 (0.63–0.93), comparing the Q2 (– mg/day) and Q5 (?1, mg/day) quintile of calcium with the lowest quintile (? mg/day), respectively. The ORs (95% CI) of Q2 (– mg/day), Q3 (– mg/day), Q4 (– mg/day), and Q5 (? mg/day) quintile of magnesium were 0.81 (0.69–0.95), 0.83 (0.70–0.98), 0.78 (0.65–0.94), and 0.69 (0.55–0.86) compared with Q1 (< mg/day).
After stratifying because of the sex, the fresh connection involving the higher and also the reasonable quintile from calcium intake and you may migraine remained statistically extreme in females and men. For fat loss magnesium, the fresh Otherwise (95% CI) are 0.62 (0.47–0.83), evaluating the greatest (? mg/d) additionally the low quintile (? mg/d) off magnesium intake in females. But not, there can be no mathematically tall connection anywhere between fat reduction magnesium consumption and you can migraine in guys (Contour step 1).
Contour step 1. Analysis was in fact shown given that Or (95% CI). Limitation outlines suggest 95% CI. ORs was in fact modified for years, race/ethnicity, smoking, sipping, marital, bhm site de rendez-vous knowledge top, Body mass index, opportunity consumption, necessary protein intake, carb intake, calcium supplements complement, magnesium enhance, vitamin D enhance, blood pressure level, all forms of diabetes, coronary arrest, coronary heart state, C reactive proteins, and you will full cholesterol levels.
We also examined the potential correlation and joint association between calcium and magnesium. We found that calcium and magnesium were highly correlated (r = 0.631; P < 0.001) (data are not shown). We divided participants into four groups based on the quintile intake of calcium and magnesium, after adjusting for potential confounders, joint analyses showed that the OR (95% CI) of migraine in the high-calcium and high-magnesium group was 0.77 (0.64–0.91) compared with the low-calcium and low-magnesium group. After stratifying by sex, the joint association of dietary calcium and magnesium remained significant in women. However, the joint association was not significant in men (Table 4).
In RCS, we observed a non-linear relationship between calcium and magnesium (continuously measured) and migraine. Significantly decreased ORs (<1.00) were observed when calcium intake ranged from 670 to 1,700 mg/day. The ORs decreased with increasing dietary magnesium levels and were significantly lower than 1.00 when dietary magnesium intake was higher than 243 mg/day (Figure 2).
Contour dos. Connection anywhere between dietary (A) calcium and you can (B) magnesium intake and horror within the RCS. The new model are adjusted to own decades, sex, race/ethnicity, puffing, taking, relationship, studies peak, Body mass index, times consumption, necessary protein consumption, carbs consumption, calcium supplements complement, magnesium supplement, vitamin D enhance, blood pressure levels, all forms of diabetes, coronary arrest, cardiovascular system condition, C activated healthy protein, and you will total cholesterol. Strong range, OR; color, 95% CI.
Conversation
Inside large cross-sectional study, we observed an inverse relationship ranging from fat loss calcium supplements and you may magnesium and you can migraine, separate of high confounders. Subgroup data showed that calcium supplements and you can magnesium stayed inversely from the migraine in females, respectively. For males, just highest weight-loss calcium intake is actually negatively linked to migraine, but there clearly was zero mathematically extreme organization between weightloss magnesium intake and you can migraine. Furthermore, into the taking a look at the latest joint aftereffects of calcium and you will magnesium, we unearthed that highest-calcium and you can high-magnesium consumption try inversely of migraine in females, in line with our very own examination of brand new separate results of calcium and you may magnesium.
